SYN-AKE is a peptide synthesized by Waglerin1 (a disruption of muscle nerve contraction) in Temple viper, a type of rattlesnake, which binds to acetylcholine receptors instead of acetylcholine to prevent syneresis to reduce muscle wrinkles .

Tripeitde with molecular weight less than 500Da synthesized by Waglerin1 small Sequence in Temple viper's poison has optimal skin penetration ability and can prevent deep wrinkles.