Name : Aloe-emodin

Systematic (IUPAC) name :1,8-dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione

CAS number :481-72-1

EINECS: 207-571-7

Formula :C15H10O5

Mol. mass :270.24

Melt. point :223–224 °C (433–435 °F) Sublimes in CO2 stream

Aloe-emodin (AE), a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antineuroectodermal tumor activity. The growth of human neuroectodermal tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the animals. The compound does not inhibit the proliferation of normal fibroblasts nor that of hemopoietic progenitor cells. The cytotoxicity mechanism consists of the induction of apoptosis, whereas the selectivity against neuroectodermal tumor cells is founded on a specific energy-dependent pathway of drug incorporation. Taking into account its unique cytotoxicity profile and mode of action, AE might represent a conceptually new lead antitumor drug.

Main Functions：

1. Anti-tumor: The Emodin has effective restrain to cell proliferation of hepatoma, lung tumor, bladder tumor and so on；

2. Protecting the Liver: Emodin protect the liver damage caused by carbon tetrachloride, and has a effective restrain to the Hepatitis B;

3. Anti-renal fibrosis: Emodin can restrain the division and proliferation of the HRIF. It can also result in the cell death by improving the level of C-MYC protein；

4. Antibiotic Action: Emodin has the inhibitory action of Staphylococcus aureus, Staphylococcus aureus(S. aureus) and Pseudomonas aeruginosa.

contact info:sales12 at staherb dot cn