Fresh frozen plasma(FFP) from whole blood 450 ml of dog : Frozen within 6 hr from collection. Volume : 250 ml/pack corona antibody > 1000 titre - It was detected by ELISA. Usage : canine corona infection, bleeding disorders(hemophillia A, Coumarin toxicosis etc), hypoproteinemia, hepatic disorders, severe dehydration. Clinical investigation for 3 years in korea proved that our hyperimmune plasma(serum) was most effective on above dog diseases.