MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase. target: BACE1. In vitro:MK-8931 can effectively reduce Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM. [1] Docking revealed that, with respect to their free binding energy, acylguanidine 7a has the lowest binding energy followed by MK-8931 and pioglitazone and binds significantly to β-secretase. [2]