HP-MTBE is an oxygenated solvent miscible with a variety of hydrocarbons, such as ketones and alcohol, among others. It is a substitute for diethyl ether, iso propyl ether, tetrahydrofuran and other solvents.

A relatively low cost solvent in organic synthesis with properties matching diethyl ether, but with a higher boiling point and lower solubility in water. - HP MTBE possesses one distinct benefit over most ethers - it has a much lower tendency to form explosive organic peroxides.

It is used as an extractant solvent for the pharmaceutical synthesis and also in the synthesis of Grignard's reagent. - It has excellent solvating property.