Hydroxypropyl methylcellulose is a non-ionic cellulose mixed ether made from cotton and wood through alkalization, propylene oxide and methyl chloride etherification. It is odorless, tasteless, non-toxic, soluble in cold water and gelled in hot water. Hydroxypropyl methylcellulose is a cellulose mixed ether variety whose production, dosage and quality have been rapidly increasing in China in the past 15 years. It is also one of the most widely used pharmaceutical excipients at home and abroad.
Suspension-type liquid preparation is a commonly used clinical dosage form, which is a heterogeneous dispersion system in which insoluble solid drugs are dispersed in a liquid dispersion medium. The stability of the system determines the quality of the suspension liquid preparation. HPMC colloidal solution can reduce the solid-liquid interfacial tension, reduce the surface free energy of solid particles, and stabilize the heterogeneous dispersion system. It is an excellent suspending agent. HPMC is used as a thickener for eye drops, with a content of 0.45% to 1.0%.
As a sustained and controlled release material for oral preparations.
HPMC has good film-forming properties. The film formed by it is uniform, transparent and tough, and it is not easy to stick during production. Especially for drugs that are easy to absorb moisture and are unstable, using it as an isolation layer can greatly improve the stability of the drug and prevent The film changes color. HPMC has a variety of viscosity specifications. If selected properly, the quality and appearance of coated tablets are superior to other materials. The commonly used concentration is 2% to 10%.
As capsule material.
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