Estradiol is a therapeutic agent for estrogen absorbed by the skin. Supplement the lack of 17-beta estradiol secreted by the female ovaries, while avoiding side effects caused by oral administration (breast pain, weight gain, hypertension, gallstones and abnormal liver function). Estrogen can promote cell synthesis of DNA, RNA and the corresponding tissue within a variety of different proteins.

Estradiol , also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is responsible for the development of female secondary sexual characteristics such as the breasts, widening of the hips, and a feminine pattern of fat distribution in women and is important in the development and maintenance of female reproductive tissues such as the mammary glands, uterus, and vagina during puberty, adulthood, and pregnancy. It also has important effects in many other tissues including bone, fat, skin, liver, and the brain. While estradiol levels in men are much lower compared to those in women, estradiol has important roles in men as well. Aside from humans and other mammals, estradiol is also found in most vertebrates and crustaceans, insects, fish, and other animal species.

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