Mindatorin is a small molecule inhibitor of the multiple tyrosine kinase receptors. In vitro biochemical or cellular assays showed that, Mindodurin and its major active metabolites CGP62221 and CGP52421 have inhibition of the wild-type FLT 3 gene, FLT 3-ITD mutation, and tyrosine kinase domain (tyrosine kinase domain, TKD) mutation, tyrosine protein kinase KIT gene (tyrosine-protein kinase Kit, The wild-type and D816V mutants of KIT), the platelet-derived growth factor receptor α / β (platelet derived growth factor receptor, PDGFRα / β), vascular endothelial growth factor receptor-2 (vascular endothelial growth factor receptor, VE GF R-2) and serine / threonine kinase protein kinase C (protein kinase C, Activity of the members of the PKC) family. Mindurin demonstrated the ability to inhibit FLT 3 gene receptor signaling and cell proliferation to induce

Density: 1.5 ± 0.1 g / cm3 Molecular formula: C35H30N4O4 Molecular weight: 570.637 Accurate mass: 570.226685 Appearance: Powder (white and yellow) Refractive index: 1.770 Storage conditions: -20℃