Applications:

Nitenpyram is used orally with dogs and cats to control fleas. After ingestion, it begins killing fleas within 30 minutes and kills all adult fleas within 4 hours. The effects of nitenpyram last approximately 24–48 hours. Nitenpyram is safe to use on puppies and kittens as young as four weeks old if they weigh at least 2 pounds (0.91 kg). Panting and excitement have been noted in cats within 2 hours of administration. In heavily infested animals, it can cause extreme itching as the fleas die.

Nitenpyram does not kill insect eggs and has no long-term activity. Thus, it is not effective as a long-term flea preventative. It is usually used to kill nymph and adult fleas quickly on an infested animal, and combined with a longer-term flea preventative like fipronil or lufenuron to prevent reinfestation.