Pomegranate PeelExtract Ellagic Acid
Ellagic acid is a polyphenol found in pomegranate peel. It is often standardized to a minimum of 40%. Ellagic acid has been shown to have anticancer and antimicrobial properties, and it is often used in dietary supplements and skin care products.
Detection method: HPLC
Botanical Source: Pomegranate Peel
Extract Part: Peel
Extraction Type: Natural
Extraction Method: Solvent extraction
Extraction Solvent: Ethanol or water-ethanol
Detection Method: HPLC
Grade: Pharmaceutical grade
Odor: Odorless
Color: Off-white to light yellow
Appearance: Powder
CAS Number: 476-66-4
Molecular Formula: C14H6O8
Molecular Weight: 302.19 g/mol
Pharmacological Properties: Antioxidant, anti-inflammatory, anticancer, antimicrobial, hepatoprotective, neuroprotective
Application: Ellagic acid is commonly used as an ingredient in dietary supplements, functional foods, and skin care products due to its pharmacological properties. It has been studied for its potential to prevent chronic diseases such as cancer, cardiovascular disease, and Alzheimer's disease, and it has also been shown to have antimicrobial and hepatoprotective effects.
Pharmacological Properties
1. Antioxidant Properties:
Ellagic acid exhibits potent antioxidant properties due to its ability to scavenge free radicals and inhibit oxidative stress. This property makes it useful in protecting against damage caused by free radicals, which have been linked to the development of chronic diseases such as cancer, cardiovascular disease, and neurodegenerative disorders. Ellagic acid's antioxidant activity is thought to be due to its ability to activate antioxidant enzymes, such as superoxide dismutase and catalase, and to upregulate the expression of antioxidant genes.
2. Anti-Inflammatory Properties:
Ellagic acid has been shown to possess anti-inflammatory properties by inhibiting the production of pro-inflammatory cytokines and chemokines. This ability makes it useful in treating inflammatory disorders such as rheumatoid arthritis and asthma. Ellagic acid's anti-inflammatory activity is thought to be due to its ability to inhibit the activation of nuclear factor-kappa B (NF-κB), a transcription factor that plays a key role in the regulation of inflammatory responses.
3. Anticancer Properties:
Ellagic acid has been shown to possess potent anticancer properties due to its ability to inhibit tumor growth and induce apoptosis (programmed cell death) in cancer cells. Studies have demonstrated that ellagic acid can inhibit the growth of a variety of cancer cells, including breast, colon, prostate, and liver cancer cells. Ellagic acid's anticancer activity is thought to be due to its ability to modulate various signaling pathways involved in cell proliferation, differentiation, and apoptosis.
4. Antimicrobial Properties:
Ellagic acid has been shown to possess antimicrobial properties against a variety of microorganisms, including bacteria, fungi, and viruses. Studies have demonstrated that ellagic acid can inhibit the growth of bacteria such as Escherichia coli, Staphylococcus aureus, and Helicobacter pylori, as well as the growth of fungi such as Candida albicans. Ellagic acid's antimicrobial activity is thought to be due to its ability to disrupt the cell membrane of microorganisms and inhibit the activity of various enzymes involved in cell metabolism.
5. Hepatoprotective Properties:
Ellagic acid has been shown to possess hepatoprotective properties by reducing liver damage caused by various hepatotoxic agents such as alcohol and carbon tetrachloride. Studies have demonstrated that ellagic acid can inhibit the production of reactive oxygen species (ROS) and lipid peroxidation in the liver, as well as stimulate the production of antioxidant enzymes. Ellagic acid's hepatoprotective activity is thought to be due to its ability to scavenge free radicals and inhibit oxidative stress in the liver.
6. Neuroprotective Properties:
Ellagic acid has been shown to possess neuroprotective properties by reducing neuronal damage caused by oxidative stress and inflammation. Studies have demonstrated that ellagic acid can inhibit the production of pro-inflammatory cytokines and chemokines in the brain, as well as increase the production of antioxidant enzymes. Ellagic acid's neuroprotective activity is thought to be due to its ability to scavenge free radicals and inhibit oxidative stress in the brain.
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