H-Val-Pro-Pro-OH(TFA) could enhance insulin sensitivity and prevent insulin resistance in 3T3-F442A pre-adipocytes.H-Val-Pro-Pro-OH(TFA) also has anti- hypertensive and anti-inflammatory functions.H-Val-Pro Pro-OH(TFA) further enhances the expression of glucose transporter 4(GLUT4) in adipocytes and restores glucose uptake in TNF-treated adipocytes.